Trifluoroacetic acid → HCID 21498242、化合物
反応式
[NH:1]([C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([O:13][CH3:14])[CH:11]=2)[CH:6]=[CH:5][N:4]=1)[NH2:2].[F:15][C:16]([F:21])([F:20])[C:17](O)=O>>[F:15][C:16]([F:21])([F:20])[C:17]1[N:4]2[CH:5]=[CH:6][C:7]3[C:12]([C:3]2=[N:1][N:2]=1)=[CH:11][C:10]([O:13][CH3:14])=[CH:9][CH:8]=3参加物
3
実験手順
A solution of 1-hydrazino-7-methoxyisoquinoline in excess trifluoroacetic acid was allowed to reflux for 2 hours. Excess acid was removed in vacuo and the residue was slurried in water and treated with sodium bicarbonate solution. The solid was removed by filtration and recrystallized from cyclohexane to give the product in a yield of 70%; m.p. 152°-154°C.
後処理
- temperatureto reflux for 2 hours
- customExcess acid was removed in vacuo
- additiontreated with sodium bicarbonate solution
- customThe solid was removed by filtration
- customrecrystallized from cyclohexane
- customto give the product in a yield of 70%
出典と根拠
- ORDレコード
- ord-cb8697c9166b4b75ada6cfd0dbd95a89
- 出典データセット
- uspto-grants-1976_11
- 特許番号
- US03992539
反応ノート
読み込み中…