Cyclohexylamine → N-Cyclohexylacetoacetamide

HRID 1730616

反応式

HRID 1730616 の反応式
[CH2:1]=[C:2]1[O:6][C:4](=[O:5])[CH2:3]1.[CH:7]1([NH2:13])[CH2:12][CH2:11][CH2:10][CH2:9][CH2:8]1>C1C=CC=CC=1>[CH:7]1([NH:13][C:4](=[O:5])[CH2:3][C:2]([CH3:1])=[O:6])[CH2:12][CH2:11][CH2:10][CH2:9][CH2:8]1

参加物

4

反応物 2

HCID 7965CyclohexylamineHCID 12661Diketene

生成物 1

HCID 70805N-Cyclohexylacetoacetamide

試薬・触媒・溶媒 1

HCID 241Benzene溶媒2 回

実験手順

A solution of diketene (42 g.) in benzene (74 ml.) is added dropwise with vigorous stirring to a solution of cyclohexylamine (49.6 g.) in benzene (125 ml.). The rate of addition is adjusted so that a gentle reflux is maintained. The benzene is removed under vacuum and the yellow oil crystallizes upon trituation with hexane. A yield of 88.7 g. of product melting at 66°-69° C. is obtained.

後処理

  1. additionThe rate of addition
  2. temperaturea gentle reflux
  3. temperatureis maintained
  4. customThe benzene is removed under vacuum
  5. customthe yellow oil crystallizes upon trituation with hexane

出典と根拠

ORDレコード
ord-f41e8808f013472d95e642b7057a0f3c
出典データセット
uspto-grants-1976_11
特許番号
US03993637

関連ノート

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