Trifluoroacetic acid → alpha-[(Thioxomethyl)amino]benzeneacetic acid

HRID 1730858ノート

反応式

HRID 1730858 の反応式
[S:1]=[CH:2][NH:3][CH:4]([C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)[C:5]([O:7]C(C1C=CC=CC=1)C1C=CC=CC=1)=[O:6].FC(F)(F)C(O)=O.C1(OC)C=CC=CC=1>>[S:1]=[CH:2][NH:3][CH:4]([C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)[C:5]([OH:7])=[O:6]

参加物

4

反応物 3

HCID 6422Trifluoroacetic acidHCID 7519AnisoleHCID 14447407HCID 14447407、化合物

生成物 1

HCID 21492714alpha-[(Thioxomethyl)amino]benzeneacetic acid

実験手順

3.61 g. (0.01 mol.) of α-[(thioxomethyl)amino]-benzeneacetic acid, diphenylmethyl ester are added to a mixture of 30 ml. of trifluoroacetic acid and 5 ml. of anisole at 0°-5° and the mixture is stirred for ten minutes. The mixture is concentrated, sodium bicarbonate solution is added to the residue and the aqueous phase is extracted with ether. This is then layered over with fresh ether, acidified and the aqueous phase is extracted twice with ether. Concentration of the ether solution yields α-[(thioxomethyl)amino]benzeneacetic acid as an oily residue.

後処理

  1. concentrationThe mixture is concentrated
  2. additionsodium bicarbonate solution is added to the residue
  3. extractionthe aqueous phase is extracted with ether
  4. extractionthe aqueous phase is extracted twice with ether

出典と根拠

ORDレコード
ord-a642de4751af44089f5e93ca18c27aca
出典データセット
uspto-grants-1976_11
特許番号
US03994889

反応ノート

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