Sodium hydride → 1-Phthalimidopropyl-3-phenyl-5-chloroindazole

HRID 1730943

反応式

HRID 1730943 の反応式
[C:1]1([C:7]2[C:15]3[C:10](=[CH:11][CH:12]=[C:13]([Cl:16])[CH:14]=3)[NH:9][N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[H-].[Na+].[C:19]1(=[O:33])[N:23]([CH2:24][CH2:25][CH2:26]Cl)[C:22](=[O:28])[C:21]2=[CH:29][CH:30]=[CH:31][CH:32]=[C:20]12>>[C:22]1(=[O:28])[N:23]([CH:24]([C:14]2[C:13]([Cl:16])=[CH:12][CH:11]=[C:10]3[C:15]=2[C:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)=[N:8][NH:9]3)[CH2:25][CH3:26])[C:19](=[O:33])[C:20]2=[CH:32][CH:31]=[CH:30][CH:29]=[C:21]12

参加物

4

反応物 3

HCID 24758Sodium hydrideHCID 2452652-(3-Chloropropyl)-1H-isoindole-1,3(2H)-dioneHCID 6151185-Chloro-3-phenyl-1H-indazole

生成物 1

HCID 681394741-Phthalimidopropyl-3-phenyl-5-chloroindazole収率 62.2%

実験手順

By the procedure similar to that described in Example 24, 3-phenyl-5-chloroindazole (9.2 g), sodium hydride 50% pure (2.3 g) and phthalimidopropyl chloride (9.0 g) were treated to obtain 10.4 g of 1-phthalimidopropyl-3-phenyl-5-chloroindazole. Recrystallization from methanol gave a product having a melting point between 121°-122° C.

後処理

  1. additionwere treated

出典と根拠

ORDレコード
ord-4a9d886ef31340c58290ae1b777dab7a
出典データセット
uspto-grants-1976_11
特許番号
US03994890

関連ノート

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