Trifluoroacetic acid → HCID 131714943、化合物
反応式
CC(C)(OC(CN(C)C(N1CCC[C@H]1C(OCC1C=CC=CC=1)=O)=O)=O)C.FC(F)(F)C(O)=O.[C:35]1(OC)[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=1.[C:43]([CH2:46][CH2:47][N:48]([CH3:66])[C:49]([N:51]1[CH2:65][CH2:64][CH2:63][C@H:52]1[C:53]([O:55][CH2:56][C:57]1C=CC=CC=1)=[O:54])=[O:50])([OH:45])=[O:44]>>[C:43]([CH2:46][CH2:47][N:48]([CH3:66])[C:49]([N:51]1[CH2:65][CH2:64][CH2:63][C@H:52]1[C:53]([O:55][CH2:56][CH2:57][C:35]1[CH:36]=[CH:37][CH:38]=[CH:39][CH:40]=1)=[O:54])=[O:50])([OH:45])=[O:44]参加物
5
実験手順
The ester product from part (c) (2.7 g., 7.17 mmole) is treated for 1.5 hours with 10 ml. of trifluoroacetic acid and 1.6 ml. of anisole. After concentrating to dryness it is triturated with ether-hexane. The crude material is crystallized from ether to yield 2 g. of 1-[[(2-carboxyethyl)methylamino]carbonyl]-L-proline, phenylmethyl ester; m.p. 102°-104°.