Propanenitrile, 3-ethoxy- → 2-(3-Amino-2-pyrazolin-1-yl)pyridine
反応式
[Na].[NH:2]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][N:5]=1)[NH2:3].C(O[CH2:13][CH2:14][C:15]#[N:16])C>C(O)C>[NH2:16][C:15]1[CH2:14][CH2:13][N:2]([C:4]2[CH:9]=[CH:8][CH:7]=[CH:6][N:5]=2)[N:3]=1参加物
5
実験手順
A 0.58 g. amount of sodium metal is dissolved in 150 ml. of absolute ethanol, then 14.0 g. of 2-hydrazinopyridine is added followed by 12.7 g. of betaethoxypropionitrile. The reaction mixture is refluxed on a steam bath for 16 hours, then the solvent is removed in vacuo. Water is added and the solid collected by filtration. The solid is recrystallized twice from acetone to give 5.55 g. of the product of the Example as tan colored crystals, m.p. 168.5°-171° C.
後処理
- temperatureThe reaction mixture is refluxed on a steam bath for 16 hours
- customthe solvent is removed in vacuo
- additionWater is added
- filtrationthe solid collected by filtration
- customThe solid is recrystallized twice from acetone
- customto give 5.55 g
出典と根拠
- ORDレコード
- ord-4e67e853bdf443e5ae26b09991027a76
- 出典データセット
- uspto-grants-1986_11
- 特許番号
- US04622401
反応ノート
読み込み中…