Propanenitrile, 3-ethoxy- → HCID 13496625、化合物

HRID 1731652

反応式

HRID 1731652 の反応式
[Na].[NH:2]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][N:5]=1)[NH2:3].C(O[CH2:13][CH2:14][C:15]#[N:16])C>C(O)C>[NH2:16][C:15]1[CH2:14][CH2:13][N:2]([C:4]2[CH:9]=[CH:8][CH:7]=[CH:6][N:5]=2)[N:3]=1

参加物

5

反応物 3

HCID 16501Propanenitrile, 3-ethoxy-HCID 786452-HydrazinopyridineHCID 5360545Sodium

生成物 1

HCID 13496625HCID 13496625、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A 0.58 g. amount of sodium metal is dissolved in 150 ml. of absolute ethanol, then 14.0 g. of 2-hydrazinopyridine is added followed by 12.7 g. of betaethoxypropionitrile. The reaction mixture is refluxed on a steam bath for 16 hours, then the solvent is removed in vacuo. Water is added and the solid collected by filtration. The solid is recrystallized twice from acetone to give 5.55 g. of the product of the Example as tan colored crystals, m.p. 168.5°-171° C.

後処理

  1. temperatureThe reaction mixture is refluxed on a steam bath for 16 hours
  2. customthe solvent is removed in vacuo
  3. additionWater is added
  4. filtrationthe solid collected by filtration
  5. customThe solid is recrystallized twice from acetone
  6. customto give 5.55 g

出典と根拠

ORDレコード
ord-4e67e853bdf443e5ae26b09991027a76
出典データセット
uspto-grants-1986_11
特許番号
US04622401

関連ノート

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