HCID 14010268、化合物 → HCID 19863758、化合物

HRID 1731773ノート

反応式

HRID 1731773 の反応式
[ClH:1].[CH:2](=[N:9][CH2:10][CH2:11][NH:12][S:13]([N:16]([CH3:18])[CH3:17])(=[O:15])=[O:14])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[H][H]>CO.[Pd]>[ClH:1].[CH2:2]([NH:9][CH2:10][CH2:11][NH:12][S:13]([N:16]([CH3:18])[CH3:17])(=[O:15])=[O:14])[C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1

参加物

5

反応物 2

HCID 14010268HCID 14010268、化合物HCID 178418361HCID 178418361、化合物

生成物 1

HCID 19863758HCID 19863758、化合物収率 92.8%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

A solution of 3.0 g (0.011 mole) of N-benzylidene-2-[N'-[(dimethylamino)sulfonyl]amino]ethylamine hydrochloride in 100 ml of methanol was hydrogenated, at 40 psi, over 0.3 g of 10% Pd-C catalyst until hydrogen uptake ceased (20 min.). The mixture was filtered and concentrated under reduced pressure to provide 3.0 g of crude product. The NMR spectrun was consistent with the assigned structure and the crude product was utilized directly without further purification.

後処理

  1. custom(20 min.)
  2. filtrationThe mixture was filtered
  3. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-a3ed332751754a06bb2a04bb776f2e71
出典データセット
uspto-grants-1986_11
特許番号
US04623652

反応ノート

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