N-Butylbenzylamine → N-Benzyl-N-butyl-N'-(3-chlorophenyl)urea

HRID 1731834ノート

反応式

HRID 1731834 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([NH:8][C:9](=[O:17])OC2C=CC=CC=2)[CH:5]=[CH:6][CH:7]=1.[CH2:18]([NH:25][CH2:26][CH2:27][CH2:28][CH3:29])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>O1CCCC1.CCCCCC>[CH2:18]([N:25]([CH2:26][CH2:27][CH2:28][CH3:29])[C:9]([NH:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[CH:3]=1)=[O:17])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

参加物

5

反応物 2

HCID 75467N-ButylbenzylamineHCID 232110Phenyl hydrogen (3-chlorophenyl)carbonimidate

生成物 1

HCID 13733049N-Benzyl-N-butyl-N'-(3-chlorophenyl)urea

試薬・触媒・溶媒 2

HCID 8028Tetrahydrofuran溶媒2 回HCID 8058Hexane溶媒

実験手順

A solution of 1.46 g of phenyl N-(3-chlorophenyl)carbamate in 15 ml of tetrahydrofuran was added to a solution of 1.92 g of N-benzyl-n-butylamine in 20 ml of tetrahydrofuran and the mixture stirred under reflux for 24 hours. The mixture was diluted with hexane and the precipitate collected by filtration. Recrystallization from pentane afforded 1-benzyl-1-(n-butyl)-3-(3-chlorophenyl)urea, m.p. 69°-70° C.

後処理

  1. temperatureunder reflux for 24 hours
  2. filtrationthe precipitate collected by filtration
  3. customRecrystallization from pentane

出典と根拠

ORDレコード
ord-b2531c9fc7a9451e8ef34dde53f31da5
出典データセット
uspto-grants-1986_11
特許番号
US04623662

反応ノート

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