Hydrochloric Acid → Benzenemethanamine, N-butyl-2-chloro-
反応式
[CH2:1]([NH:5][C:6](=O)[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[Cl:13])[CH2:2][CH2:3][CH3:4].B.Cl>O1CCCC1>[CH2:1]([NH:5][CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[Cl:13])[CH2:2][CH2:3][CH3:4]参加物
5
実験手順
A solution of 21.2 g of N-(n-butyl)-2-chlorobenzamide in 100 ml of tetrahydrofuran was added with cooling to 200 ml of 1M borane in tetrahydrofuran and the mixture was stirred under reflux for 18 hours, allowed to cool, and treated with 6N hydrochloric acid. The organic solvent was evaporated, and the residue was partitioned between ether and aqueous sodium hydroxide solution. The ether layer was separated, dried, and evaporated. The residue was distilled to yield N-(n-butyl)-2-chlorobenzylamine as a colorless liquid, b.p. 65°-75° C. at 60μ.
後処理
- temperatureunder reflux for 18 hours
- temperatureto cool
- customThe organic solvent was evaporated
- customthe residue was partitioned between ether and aqueous sodium hydroxide solution
- customThe ether layer was separated
- customdried
- customevaporated
- distillationThe residue was distilled
出典と根拠
- ORDレコード
- ord-abe5a0a39ea04013bb2d3a2d3bd39f67
- 出典データセット
- uspto-grants-1986_11
- 特許番号
- US04623662
反応ノート
読み込み中…