Hydrochloric Acid → N-heptyl-4-butylbenzenemethanamine

HRID 1731852ノート

反応式

HRID 1731852 の反応式
[CH2:1]([NH:8][C:9](=O)[C:10]1[CH:15]=[CH:14][C:13]([CH2:16][CH2:17][CH2:18][CH3:19])=[CH:12][CH:11]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH3:7].Cl>O1CCCC1>[CH2:1]([NH:8][CH2:9][C:10]1[CH:15]=[CH:14][C:13]([CH2:16][CH2:17][CH2:18][CH3:19])=[CH:12][CH:11]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH3:7]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 13733121Benzamide, 4-butyl-N-heptyl-

生成物 1

HCID 15137718N-heptyl-4-butylbenzenemethanamine

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

A solution of 38.0 g of N-heptyl-4-n-butylbenzamide and 280 ml of borane-tetrahydrofuran complex in 120 ml of anhydrous tetrahydrofuran was refluxed for 18 hours, allowed to cool, and treated with 6N hydrochloric acid. The organic solvent was evaporated and the residue was partitioned between ether and aqueous sodium hydroxide solution. The ether layer was separated, dried, and evaporated. The residue was distilled to yield N-heptyl-4-n-butylbenzenemethanamine as a colorless liquid, bp 115° C. at 80μ.

後処理

  1. temperatureto cool
  2. customThe organic solvent was evaporated
  3. customthe residue was partitioned between ether and aqueous sodium hydroxide solution
  4. customThe ether layer was separated
  5. customdried
  6. customevaporated
  7. distillationThe residue was distilled

出典と根拠

ORDレコード
ord-bf5ed8ed898c4da5ae774386f939729f
出典データセット
uspto-grants-1986_11
特許番号
US04623662

反応ノート

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