N-bromobutanimide → 5-(Bromomethyl)-α-methyl-2-nitrobenzenemethanol

HRID 1732078ノート

反応式

HRID 1732078 の反応式
[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([N+:11]([O-:13])=[O:12])=[C:6]([C:8](=[O:10])[CH3:9])[CH:7]=1.[Br:14]N1C(=O)CCC1=O>>[Br:14][CH2:1][C:2]1[CH:3]=[CH:4][C:5]([N+:11]([O-:13])=[O:12])=[C:6]([CH:8]([OH:10])[CH3:9])[CH:7]=1

参加物

3

反応物 2

HCID 67184N-bromobutanimideHCID 11769120HCID 11769120、化合物

生成物 1

HCID 202265155-(Bromomethyl)-α-methyl-2-nitrobenzenemethanol

実験手順

Compound 2 is synthesized in two steps from 1-(5-methyl-2-nitrophenyl) ethanone (1), which can be obtained as described by Doppler et al. (1979) Helv. Chem. Acta 62:291-303. Specifically, the ring methyl group is brominated using N-bromosuccinimide and then the benzylic ketone is reduced to an alcohol. Those procedures are described below.

後処理

  1. customcan be obtained

出典と根拠

ORDレコード
ord-4b37a79c79a94d5bb2f61fd5cc7a7955
出典データセット
uspto-grants-1986_11
特許番号
US04625014

反応ノート

読み込み中…