1-Methyl-6-phenylpyrimidine-2,4(1H,3H)-dione → 1-Methyl-6-phenyldihydropyrimidine-2,4(1H,3H)-dione

HRID 1732103ノート

反応式

HRID 1732103 の反応式
[CH3:1][N:2]1[C:9]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[CH:8][C:6](=[O:7])[NH:5][C:3]1=[O:4]>CN(C)C=N.[Pd]>[CH3:1][N:2]1[CH:9]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH2:8][C:6](=[O:7])[NH:5][C:3]1=[O:4]

参加物

4

反応物 1

HCID 123003501-Methyl-6-phenylpyrimidine-2,4(1H,3H)-dione

生成物 1

HCID 130862351-Methyl-6-phenyldihydropyrimidine-2,4(1H,3H)-dione

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 12669390N,N-Dimethylmethanimidamide溶媒

実験手順

A solution of 1-methyl-6-phenyluracil (0.65 g) in dimethylformamidine (15 ml) is treated with 10 percent palladium on carbon and reduced at 40 p.s.i. for 20 hours. The catalyst is then filtered and the filtrate evaporated to a crystalline residue. The crystallization from acetonitrile provides 5,6-dihydro-1-methyl-6-phenyl-2,4-pyrimidine-dione, m.p. 155°-6° C.

後処理

  1. filtrationThe catalyst is then filtered
  2. customthe filtrate evaporated to a crystalline residue
  3. customThe crystallization from acetonitrile

出典と根拠

ORDレコード
ord-4160537650e34c018ad921db6c839db3
出典データセット
uspto-grants-1986_11
特許番号
US04625028

反応ノート

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