alpha-Pentyl-3-(2-quinolinylmethoxy)benzenemethanol → HCID 20226648、化合物

HRID 1732107ノート

反応式

HRID 1732107 の反応式
[OH:1][CH:2]([C:8]1[CH:9]=[C:10]([CH:23]=[CH:24][CH:25]=1)[O:11][CH2:12][C:13]1[CH:22]=[CH:21][C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[N:14]=1)[CH2:3][CH2:4][CH2:5][CH2:6][CH3:7].ClC1C=C(C=CC=1)C(OO)=[O:31]>C(Cl)Cl>[OH:1][CH:2]([C:8]1[CH:9]=[C:10]([CH:23]=[CH:24][CH:25]=1)[O:11][CH2:12][C:13]1[CH:22]=[CH:21][C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[N+:14]=1[O-:31])[CH2:3][CH2:4][CH2:5][CH2:6][CH3:7]

参加物

4

反応物 2

HCID 5059alpha-Pentyl-3-(2-quinolinylmethoxy)benzenemethanolHCID 70297m-Chloroperbenzoic acid

生成物 1

HCID 20226648HCID 20226648、化合物収率 37.9%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A mixture of 5.0 g (0.015 mol) 2-[3-(1-hydroxyhexyl)phenoxymethyl]quinoline and 3.0 g (0.017 mol) m-chloroperoxybenzoic acid in 100 ml CH2Cl2 was stirred at room temperature for a period of 24 hours. The reaction mixture was extracted with dilute NaHCO3 solution, washed with water, dried over MgSO4 and concentrated to dryness under reduced pressure. The residue was triturated with large amounts of ether to obtain a solid. This solid was filtered, washed with ether and dried to give the desired compound (2 g).

後処理

  1. extractionThe reaction mixture was extracted with dilute NaHCO3 solution
  2. washwashed with water
  3. dry with materialdried over MgSO4
  4. concentrationconcentrated to dryness under reduced pressure
  5. customThe residue was triturated with large amounts of ether
  6. customto obtain a solid
  7. filtrationThis solid was filtered
  8. washwashed with ether
  9. customdried

出典と根拠

ORDレコード
ord-38e7f46ede484771ad4cd0da699b6744
出典データセット
uspto-grants-1986_11
特許番号
US04625034

反応ノート

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