Water → 2-Benzyl-2-methyl-3-butenitrile

HRID 1732144

反応式

HRID 1732144 の反応式
O.[CH2:2](Cl)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[CH3:10][C:11](=[CH:14][CH3:15])[C:12]#[N:13].[OH-].[Na+]>[Br-].C([N+](CCCC)(CCCC)CCCC)CCC.C1(C)C=CC=CC=1>[CH3:10][C:11]([CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1)([CH:14]=[CH2:15])[C:12]#[N:13]

参加物

7

反応物 4

HCID 962WaterHCID 7503Benzyl ChlorideHCID 14798Sodium HydroxideHCID 299352-Methyl-2-butenenitrile

生成物 1

HCID 54638042-Benzyl-2-methyl-3-butenitrile

試薬・触媒・溶媒 2

HCID 74236Tetrabutylammonium Bromide触媒HCID 1140Toluene溶媒

実験手順

Into a 500 ml 4-neck flask, equipped with a stirrer, reflux cooler, dropping funnel and water separator, 126.5 g (1 mole) of benzylchloride, 81 g (1 mole) of 2-methyl-2-butene-nitrile, 100 ml of toluene, and 10 g of tetrabutylammonium bromide were first introduced and heated to reflux. To this mixture, 40 g (1 mole) of solid sodium hyroxide were added in portions. The reaction mixture was then maintained one more hour at reflux. Thereupon, it was washed to neutrality with water, the phases were separated and the organic phase distilled as described in Example 1. The yield in desired product was 103.5 g, corresponding to 61% of the theoretical.

後処理

  1. customInto a 500 ml 4-neck flask, equipped with a stirrer
  2. temperaturereflux cooler
  3. temperatureheated to reflux
  4. temperatureThe reaction mixture was then maintained one more hour
  5. temperatureat reflux
  6. washThereupon, it was washed
  7. customthe phases were separated
  8. distillationthe organic phase distilled

出典と根拠

ORDレコード
ord-e90031ab58bd475f9e2ba9098024d0ba
出典データセット
uspto-grants-1986_11
特許番号
US04625046

関連ノート

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