Allyl chloride → HCID 54210645、化合物

HRID 1732145ノート

反応式

HRID 1732145 の反応式
[OH-].[Na+].[CH2:3]([C:6](=[CH:9][CH2:10][CH3:11])[C:7]#[N:8])[CH2:4][CH3:5].[CH2:12](Cl)[CH:13]=[CH2:14]>[Br-].C([N+](CCCC)(CCCC)CCCC)CCC.C1(C)C=CC=CC=1>[CH2:9]([C:6]([CH2:12][CH2:13][CH3:14])([CH:3]=[CH:4][CH3:5])[C:7]#[N:8])[CH:10]=[CH2:11]

参加物

6

反応物 3

HCID 7850Allyl chlorideHCID 14798Sodium HydroxideHCID 53943258HCID 53943258、化合物

生成物 1

HCID 54210645HCID 54210645、化合物収率 35.9%

試薬・触媒・溶媒 2

HCID 74236Tetrabutylammonium Bromide触媒HCID 1140Toluene溶媒

反応条件

温度
80 °C

実験手順

Into a 250 ml 4-neck flask equipped with stirrer, reflux cooler and dropping funnel, 20 g (0.5 moles) of solid sodium hydroxide, 80 ml of toluene and 5 g of tetrabutylammonium bromide are first introduced and heated to 80° C. To this 2-phase system, a mixture of 50 g (0.41 moles) of 2-propyl-2-pentenenitrile and 31.4 g (0.41 moles) of allyl chloride were added in doses within 30 minutes. The reaction mixture was maintained for 2 more hours at a temperature of 75° C. Further work proceeded as in Example 1. A yield of 24 g of desired product, corresponding to 29.4% of the theoretical, was obtained.

後処理

  1. customInto a 250 ml 4-neck flask equipped with stirrer
  2. temperaturereflux cooler
  3. additionwere added in doses within 30 minutes
  4. temperatureThe reaction mixture was maintained for 2 more hours at a temperature of 75° C

出典と根拠

ORDレコード
ord-a697c163825d4c26a8852fe8b5846697
出典データセット
uspto-grants-1986_11
特許番号
US04625046

反応ノート

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