Sodium Hydroxide → N-[2-(Dimethylamino)ethyl]acrylamide

反応式

[CH3:1][N:2]([CH3:12])[CH2:3][CH2:4][NH:5][C:6](=[O:11])[CH2:7][CH2:8]OC.[OH-].[Na+]>>[CH3:1][N:2]([CH3:12])[CH2:3][CH2:4][NH:5][C:6](=[O:11])[CH:7]=[CH2:8]

参加物

反応物 2

HCID 14798Sodium Hydroxide

HCID 2030583674302-23-1

生成物 1

HCID 70218N-[2-(Dimethylamino)ethyl]acrylamide

実験手順

174.2 g (1.0 mole) of N-(2-dimethylaminoethyl)-3-methoxypropionamide (according to Example 17) are heated with 1.5 g of sodium hydroxide in a high vacuum at 90° to 110° C. Within about 30 minutes the methanol is split off, vigorous foaming occurring. The temperature is increased and 85 g (0.6 mole=60% of the theoretical yield) of colorless oil having a Bp0.1 of 85°-90° C. are distilled off.

後処理

customWithin about 30 minutes the methanol is split off
temperatureThe temperature is increased
custom85 g (0.6 mole=60% of the theoretical yield) of colorless oil
customa Bp0.1 of 85°-90° C.
distillationare distilled off

出典と根拠

ORDレコード: ord-d258cf40b583466fb826c43a4af6a163
出典データセット: uspto-grants-1980_12
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04237067

反応ノート

読み込み中…

参加物