p-Toluenesulfonic acid → HCID 44562749、化合物

HRID 1732435ノート

反応式

HRID 1732435 の反応式
C(OC([C:8]1([CH2:19]/[CH:20]=[CH:21]\[CH2:22][CH3:23])[C:12](=[O:13])[CH:11]=[CH:10][CH:9]1[CH2:14][C:15]([O:17][CH3:18])=[O:16])=O)(C)(C)C.C1(C)C=CC(S(O)(=O)=O)=CC=1.C(=O)(O)[O-].[Na+]>C1C=CC=CC=1>[CH3:18][O:17][C:15]([CH2:14][CH:9]1[CH:8]([CH2:19]/[CH:20]=[CH:21]\[CH2:22][CH3:23])[C:12](=[O:13])[CH:11]=[CH:10]1)=[O:16]

参加物

5

反応物 3

HCID 6101p-Toluenesulfonic acidHCID 516892Sodium BicarbonateHCID 70583183HCID 70583183、化合物

生成物 1

HCID 44562749HCID 44562749、化合物

試薬・触媒・溶媒 1

HCID 241Benzene溶媒

実験手順

A 540 mg quantity of 5-tert-butoxycarbonyl-4-methoxycarbonylmethyl-5-(cis-2-pentenyl)-2-cyclopentenone and 10 mg of p-toluene sulfonic acid are dissolved in 20 ml of benzene, and the solution is refluxed for 20 minutes. The resulting reaction mixture is neutralized with sodium bicarbonate. The solvent is distilled off from the mixture, and the residue is distilled in a vacuum, giving 4-methoxycarbonylmethyl-5-(cis-2-pentenyl)-2-cyclopentenone (compound (1-a), R2 =CH3) in a yield of 91%, b.p. 88°-92° C./2.5 mm Hg.

後処理

  1. temperaturethe solution is refluxed for 20 minutes
  2. customThe resulting reaction mixture
  3. distillationThe solvent is distilled off from the mixture
  4. distillationthe residue is distilled in a vacuum

出典と根拠

ORDレコード
ord-25bc667b2d7044aaa2fde8596d3e6644
出典データセット
uspto-grants-1980_12
特許番号
US04237308

反応ノート

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