Ethyl phenylacetate → HCID 3599665、化合物

HRID 1732647ノート

反応式

HRID 1732647 の反応式
[Na].[C:2]1([C:8](=[N:17][NH2:18])[C:9]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=O)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:19]1([CH2:25][C:26](OCC)=[O:27])[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>C(O)C>[C:19]1([C:25]2[C:26](=[O:27])[NH:18][N:17]=[C:8]([C:2]3[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=3)[C:9]=2[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

参加物

5

反応物 3

HCID 7590Ethyl phenylacetateHCID 792892-Hydrazinylidene-1,2-diphenylethanoneHCID 5360545Sodium

生成物 1

HCID 3599665HCID 3599665、化合物収率 30%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

Sodium (11.5 g) was allowed to react with ethanol and then benzilmonohydrazone (120 g) and ethyl phenylacetate (84 g) were added and the reaction mixture heated at reflux for 3 hours. The reaction was quenched in water and the suspension acidified. The resulting precipitate was separated and refluxed with acetonitrile, cooled and separated by filtration to obtain 4,5,6-triphenyl-2H-pyridazin-3-one (30 percent yield), m.p. 290°-292° C.

後処理

  1. temperaturethe reaction mixture heated
  2. temperatureat reflux for 3 hours
  3. customThe reaction was quenched in water
  4. customThe resulting precipitate was separated
  5. temperaturerefluxed with acetonitrile
  6. temperaturecooled
  7. customseparated by filtration

出典と根拠

ORDレコード
ord-55950ba73e8b432b8932beb92676e01b
出典データセット
uspto-grants-1980_12
特許番号
US04238490

反応ノート

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