Hydrogen Bromide → HCID 5323829、化合物

HRID 1732858ノート

反応式

HRID 1732858 の反応式
[CH3:1][C:2]12[CH:9](O)[C:6]([CH3:11])([CH2:7][CH2:8]1)[CH2:5][CH2:4][CH2:3]2.[BrH:12]>>[CH3:1][C:2]12[CH:9]([Br:12])[C:6]([CH3:11])([CH2:7][CH2:8]1)[CH2:5][CH2:4][CH2:3]2

参加物

3

反応物 2

HCID 260Hydrogen BromideHCID 1084411,5-Dimethylbicyclo[3.2.1]octan-8-ol

生成物 1

HCID 5323829HCID 5323829、化合物収率 85.1%

実験手順

1,5-dimethyl-8-hydroxy bicyclo[3,2,1]octane (13.6 g (0.1 mol)) was boiled with 50 ml 48% hydrogen bromide for 4 hours under stirring in the presence of 1 g AMBERLYST A15 ion-exchange resin. The reaction product was extracted after cooling with pentane. The pentane layer was washed with water and a diluted sodium bicarbonate solution. After drying over anhydrous sodium sulfate and boiling down pentane the residue was subjected to fractional distillation under reduced pressure. 18.5 g 1,5-dimethyl-8-bromobicyclo[3,2,1]octane was obtained in 85.1% yield (b.p. 93° C./10 mm Hg). The product obtained was identical with the compound according to the process described in Example 2a.

後処理

  1. extractionThe reaction product was extracted
  2. temperatureafter cooling with pentane
  3. washThe pentane layer was washed with water
  4. dry with materialAfter drying over anhydrous sodium sulfate
  5. distillationwas subjected to fractional distillation under reduced pressure

出典と根拠

ORDレコード
ord-971ba37469444c3c91e3311e2dce7b17
出典データセット
uspto-grants-1980_12
特許番号
US04239707

反応ノート

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