Chloroacetonitrile → 3-Amino-6-methylthieno[2,3-b]pyridine-2-carbonitrile

HRID 1732917ノート

反応式

HRID 1732917 の反応式
[SH:1][C:2]1[C:7]([C:8]#[N:9])=[CH:6][CH:5]=[C:4]([CH3:10])[N:3]=1.C[O-].[Na+].Cl[CH2:15][C:16]#[N:17]>CO>[NH2:9][C:8]1[C:7]2[C:2](=[N:3][C:4]([CH3:10])=[CH:5][CH:6]=2)[S:1][C:15]=1[C:16]#[N:17]

参加物

5

反応物 3

HCID 7856ChloroacetonitrileHCID 10942334Sodium MethoxideHCID 178425618HCID 178425618、化合物

生成物 1

HCID 7023133-Amino-6-methylthieno[2,3-b]pyridine-2-carbonitrile

試薬・触媒・溶媒 1

HCID 887Methanol溶媒2 回

実験手順

To a solution of 7.5 g. (0.05 mole) of 2-mercapto-3-cyano-6-methylpyridine in 200 ml. of MeOH was added 5.4 g. (0.1 M) sodium methoxide. Stirring was continued until all dissolved. 8.0 g. (0.1 M) of chloroacetonitrile in 20 ml. methanol was then added and the mixture was refluxed for 6 hours. After removal of the solvent, the residue was diluted with water and filtered. The crude product was crystallized from methanol, m.p. 241°-242° C. (Offin No. 2,241,717 in 3/4/74 reported m.p. 241°-243°).

後処理

  1. temperaturethe mixture was refluxed for 6 hours
  2. customAfter removal of the solvent
  3. additionthe residue was diluted with water
  4. filtrationfiltered
  5. customThe crude product was crystallized from methanol, m.p. 241°-242° C. (Offin No. 2,241,717 in 3/4/74 reported m.p. 241°-243°)

出典と根拠

ORDレコード
ord-dd319e3988c044358deb8d138d602980
出典データセット
uspto-grants-1980_12
特許番号
US04239887

反応ノート

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