Sulfuryl chloride → Methyl 4-acetoxythiophene-3-carboxylate

HRID 1732939ノート

反応式

HRID 1732939 の反応式
[CH3:1][O:2][C:3]([C:5]1[CH:6]([O:10][C:11](=[O:13])[CH3:12])[CH2:7][S:8][CH:9]=1)=[O:4].S(Cl)(Cl)(=O)=O>C(Cl)(Cl)Cl>[CH3:1][O:2][C:3]([C:5]1[C:6]([O:10][C:11](=[O:13])[CH3:12])=[CH:7][S:8][CH:9]=1)=[O:4]

参加物

4

反応物 2

HCID 24648Sulfuryl chlorideHCID 542465723-Acetoxy-dihydrothiophene-4-carboxylic acid methyl ester

生成物 1

HCID 12520003Methyl 4-acetoxythiophene-3-carboxylate収率 91%

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

4.04 Parts of 3-acetoxy-dihydrothiophene-4-carboxylic acid methyl ester are reacted with 1.76 parts by volume of sulfuryl chloride in 50 parts by volume of chloroform in the course of one hour at 0° C. The end product is isolated from the reaction mixture by the method described in Example 1c. 3.64 parts (91% of theory) of 3-acetoxy-thiophene-4-carboxylic acid methyl ester of melting point 56°-58° C. are obtained.

後処理

  1. customThe end product is isolated from the reaction mixture by the method

出典と根拠

ORDレコード
ord-bab7425532424fa7b0f08caf8aea1cfb
出典データセット
uspto-grants-1980_12
特許番号
US04239897

反応ノート

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