2-Propenal, 3-[4-(1,1-dimethylethyl)phenyl]-2-methyl- → 3-(4-tert-Butylphenyl)-2-methylprop-2-en-1-ol

HRID 1733273

反応式

HRID 1733273 の反応式
[C:1]([C:5]1[CH:10]=[CH:9][C:8]([CH:11]=[C:12]([CH3:15])[CH:13]=[O:14])=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[BH4-].[Na+]>CO>[C:1]([C:5]1[CH:6]=[CH:7][C:8]([CH:11]=[C:12]([CH3:15])[CH2:13][OH:14])=[CH:9][CH:10]=1)([CH3:4])([CH3:2])[CH3:3]

参加物

4

反応物 2

HCID 1146592-Propenal, 3-[4-(1,1-dimethylethyl)phenyl]-2-methyl-HCID 4311764Sodium borohydride

生成物 1

HCID 543813673-(4-tert-Butylphenyl)-2-methylprop-2-en-1-ol

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

404.5 g of 3-(p-tert.butyl-phenyl)-2-methyl-acrolein are dissolved in 2500 ml of methanol and treated portionwise with 38 g of sodium borohydride while cooling with ice. Subsequently, the mixture is stirred at room temperature for 2.5 hours, poured into 2500 ml of ice-cold 2-N hydrochloric acid and exhaustively extracted with hexane. The combined hexane extracts are washed neutral with water, dried over sodium sulphate and evaporated. Vacuum distillation yields pure 3-(p-tert.butyl-phenyl)-2-methyl-allyl alcohol of boiling point 119° C./0.005 Torr.

後処理

  1. temperaturewhile cooling with ice
  2. extractionexhaustively extracted with hexane
  3. washThe combined hexane extracts are washed neutral with water
  4. dry with materialdried over sodium sulphate
  5. customevaporated
  6. distillationVacuum distillation

出典と根拠

ORDレコード
ord-c9b3e26ab02241aaa76378731f7f9858
出典データセット
uspto-grants-1980_12
特許番号
US04241058

関連ノート

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