Bromopyruvic Acid → 3-(Bromomethyl)-1,2-dihydroquinoxalin-2-one

HRID 1733456

反応式

HRID 1733456 の反応式
[2H][C:2]1[C:7]([2H])=[C:6]([NH2:9])[C:5]([NH2:10])=[C:4]([2H])[C:3]=1[2H].[Br:13][CH2:14][C:15](=O)[C:16](O)=[O:17]>O1CCCC1>[Br:13][CH2:14][C:15]1[C:16](=[O:17])[NH:10][C:5]2[C:6]([N:9]=1)=[CH:7][CH:2]=[CH:3][CH:4]=2

参加物

4

反応物 2

HCID 70684Bromopyruvic AcidHCID 107729501,2-Diaminobenzene (D4, 98%)

生成物 1

HCID 2862543-(Bromomethyl)-1,2-dihydroquinoxalin-2-one

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

O-phenylenediamine (1.0 g., 0.0092 mol.) was dissolved in tetrahydrofuran (50 ml.) and 3-bromopyruvic acid (1.7 g., 0.0102 mol.) added. The reaction mixture was stirred at room temperature for one hour, during which time the product precipitated as a yellow solid. The product was collected by filtration and crystallized from methylene chloride. (0.91 g., m.p. 221°-223° (dec.) 41%)

後処理

  1. customprecipitated as a yellow solid
  2. filtrationThe product was collected by filtration
  3. customcrystallized from methylene chloride

出典と根拠

ORDレコード
ord-8c0b00446bff46fc9896b1235fb35277
出典データセット
uspto-grants-1980_12
特許番号
US04242342

関連ノート

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