Piperazine → HCID 20299635、化合物
反応式
Cl[C:2]1[N:3]=[CH:4][C:5]2[N:6]([C:8]([S:11][C:12]([F:15])([F:14])[F:13])=[CH:9][N:10]=2)[CH:7]=1.[NH:16]1[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]1>C(#N)C>[N:16]1([C:2]2[N:3]=[CH:4][C:5]3[N:6]([C:8]([S:11][C:12]([F:15])([F:14])[F:13])=[CH:9][N:10]=3)[CH:7]=2)[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]1参加物
4
実験手順
6-Chloro-3-trifluoromethylthioimidazo[1,2-a]pyrazine from Step A is reacted with piperazine (2 g) in efluxing acetonitrile for 24 hours. The mixture is cooled, concentrated under vacuum, and the esidue partitioned between dilute sodium hydroxide and chloroform. The chloroform extract is dried over sodium sulfate, filtered and concentrated under vacuum to the crude base which is purified by chromatography on silica gel and converted to 6-(1-piperazinyl)-3-trifluoromethylthioimidazo[1,2-a]pyrazine hydrochloride with ethanolic hydrogen chloride.