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Pyridine → N-[4-(hexadecylamino)benzoyl]-2-methylalanine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Pyridine | HCID 1049 | — |
| 反応物 | Aminoisobutyric acid | HCID 6119 | — |
| 反応物 | 4-Hexadecylaminobenzoyl chloride hydrochloride | HCID 13255322 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | N-[4-(hexadecylamino)benzoyl]-2-methylalanine | HCID 20437359 | — |
反応手順
A mixture of 5.24 g. of α-aminoisobutyric acid, 50 ml. of pyridine, and 25 ml. of H2O was stirred while 21.1 g. of 4-(hexadecylamino)benzoyl chloride hydrochloride was added. The mixture was stirred for 18 hours at ambient temperature and filtered. The filtrate was evaporated and the residual yellow glass was dissolved in 1 N NaOH solution. The solution was extracted with diethyl ether and then acidified with 6 N HCl. The precipitate was collected, dried, and recrystallized from acetone, melting point 199°-202° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04242273 |
| 出典データセット | uspto-grants-1980_12 |
| ORD ID | ord-a2a339dc721d4809a78cdb8ca5e5ee85 |
| 出典メモ | uspto-grants-1980_12 |