反应详情

A mixture of 5.24 g. of α-aminoisobutyric acid, 50 ml. of pyridine, and 25 ml. of H2O was stirred while 21.1 g. of 4-(hexadecylamino)benzoyl chloride hydrochloride was added. The mixture was stirred for 18 hours at ambient temperature and filtered. The filtrate was evaporated and the residual yellow glass was dissolved in 1 N NaOH solution. The solution was extracted with diethyl ether and then acidified with 6 N HCl. The precipitate was collected, dried, and recrystallized from acetone, melting point 199°-202° C.

1. additionA mixture of 5.24 g
2. filtrationfiltered
3. customThe filtrate was evaporated
4. dissolutionthe residual yellow glass was dissolved in 1 N NaOH solution
5. extractionThe solution was extracted with diethyl ether
6. customThe precipitate was collected
7. customdried
8. customrecrystallized from acetone, melting point 199°-202° C.