Benzenamine hydrochloride (1:1) → N-Phenylcyclohexanecarboxamide

HRID 1733867ノート

反応式

HRID 1733867 の反応式
[CH:1]1([C:7](Cl)=[O:8])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.Cl.[NH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.C(N(CC)C(C)C)(C)C>ClCCl>[C:12]1([NH:11][C:7]([CH:1]2[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]2)=[O:8])[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

参加物

5

反応物 3

HCID 8870Benzenamine hydrochloride (1:1)HCID 75938Cyclohexanecarbonyl chlorideHCID 81531Diisopropylethylamine

生成物 1

HCID 257030N-Phenylcyclohexanecarboxamide収率 91.5%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Cyclohexanecarbonyl chloride (14.66 g, 0.1 mol) was added dropwise to a stirred solution of aniline hydrochloride (12.96 g 0.1 mol) and N, N-diisopropylethylamine (15.20 g, 0.2 mol) in dichloromethane (100 ml). The solution was stirred under an atmosphere of argon for 18 h, washed with 0.1 N-HC1 (3×50 ml) and dilute sodium hydrogen carbonate solution (50 ml), dried (MgSO4), and evaporated in vacuo to give the product (18.6 g) as white crystals.

後処理

  1. washwashed with 0.1 N-HC1 (3×50 ml) and dilute sodium hydrogen carbonate solution (50 ml)
  2. dry with materialdried (MgSO4)
  3. customevaporated in vacuo

出典と根拠

ORDレコード
ord-509746ea222e4554990b76ad038f14ee
出典データセット
uspto-grants-1996_07
特許番号
US05532242

反応ノート

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