Benzene → 6-Amidino-2-naphthyl 5-(3-methoxycarbonylpropionylaminomethyl)furan-2-carboxylate hydrochloride

HRID 1734109ノート

反応式

HRID 1734109 の反応式
Cl.Cl.[NH2:3][CH2:4][C:5]1[O:9][C:8]([C:10]([O:12][C:13]2[CH:22]=[CH:21][C:20]3[C:15](=[CH:16][CH:17]=[C:18]([C:23](=[NH:25])[NH2:24])[CH:19]=3)[CH:14]=2)=[O:11])=[CH:7][CH:6]=1.N1C=CC=CC=1.C1C=CC=CC=1.[CH3:38][O:39][C:40]([CH2:42][CH2:43][C:44]([Cl:46])=[O:45])=[O:41]>CN(C=O)C.CCOCC>[ClH:46].[CH3:38][O:39][C:40]([CH2:42][CH2:43][C:44]([NH:3][CH2:4][C:5]1[O:9][C:8]([C:10]([O:12][C:13]2[CH:22]=[CH:21][C:20]3[C:15](=[CH:16][CH:17]=[C:18]([C:23](=[NH:24])[NH2:25])[CH:19]=3)[CH:14]=2)=[O:11])=[CH:7][CH:6]=1)=[O:45])=[O:41]

参加物

7

反応物 4

HCID 241BenzeneHCID 1049PyridineHCID 73888Butanoic acid, 4-chloro-4-oxo-, methyl esterHCID 223988156-Amidino-2-naphthyl 5-aminomethylfuran-2-carboxylate dihydrochloride

生成物 1

HCID 223988166-Amidino-2-naphthyl 5-(3-methoxycarbonylpropionylaminomethyl)furan-2-carboxylate hydrochloride

試薬・触媒・溶媒 2

HCID 3283Diethyl Ether溶媒HCID 6228Dimethylformamide溶媒

実験手順

To a solution of 18 g of 6-amidino-2-naphthyl 5-aminomethylfuran-2-carboxylate dihydrochloride in 380 ml of DMF was added 19.1 ml of pyridine and then, while cooling with ice, 20 ml of a benzene solution containing 7.5 ml of 3-methoxycarbonylpropionyl chloride was added dropwise thereto for 20 minutes. After stirring at room temperature for 2.5 hours, the reaction mixture was added to 2 l of ether while stirring and cooling with ice, and the mixture was stirred at the same temperature for 5 hours. The supernatant was decanted and 1.5 l of ether was further added and stirred at room temperature for 18 hours. The precipitate was collected by filtration, 800 ml of acetone was added thereto, the mixture was stirred at room temperature for 5 hours, and the crystals were collected by filtration to obtain 19.6 g of the intended product.

後処理

  1. additionwas added dropwise
  2. stirringwhile stirring
  3. temperaturecooling with ice
  4. stirringthe mixture was stirred at the same temperature for 5 hours
  5. customThe supernatant was decanted
  6. addition1.5 l of ether was further added
  7. stirringstirred at room temperature for 18 hours
  8. filtrationThe precipitate was collected by filtration, 800 ml of acetone
  9. additionwas added
  10. stirringthe mixture was stirred at room temperature for 5 hours
  11. filtrationthe crystals were collected by filtration

出典と根拠

ORDレコード
ord-ffdf86ec4dd8478b9bd4c0f2c6af4399
出典データセット
uspto-grants-1996_07
特許番号
US05532267

反応ノート

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