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Hydrogen Bromide → 6-(Bromomethyl)-2,4-diaminopyrido [2,3-d]pyrimidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrogen Bromide | HCID 260 | — |
| 反応物 | 2,4-Diamino-6-(hydroxymethyl)pyrido[2,3-d]pyrimidine | HCID 487416 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 生成物 | 6-(Bromomethyl)-2,4-diaminopyrido [2,3-d]pyrimidine | HCID 10562861 | — |
反応手順
The intermediate III-2 was prepared from 2,4-diaminopyrido [2,3-d]pyrimidine-6-methanol (III-1) by the procedure described in J. Med. Chem., 35:332 (1992). This particular preparation analyzed for a 1.75 HBr° 0.25 CH3COOH salt (formula wt. 406.7). The material was suitable for conversions to compound 33.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05536724 |
| 出典データセット | uspto-grants-1996_07 |
| ORD ID | ord-4519af7ad0c042d9b7c1e74387c6d76a |
| 出典メモ | uspto-grants-1996_07 |