Hydrogen Bromide → 6-(Bromomethyl)-2,4-diaminopyrido [2,3-d]pyrimidine

HRID 1735132Notes

Reaction equation

HRID 1735132 reaction equation
[NH2:1][C:2]1[N:3]=[C:4]([NH2:14])[C:5]2[CH:11]=[C:10]([CH2:12]O)[CH:9]=[N:8][C:6]=2[N:7]=1.[BrH:15]>CC(O)=O>[Br:15][CH2:12][C:10]1[CH:9]=[N:8][C:6]2[N:7]=[C:2]([NH2:1])[N:3]=[C:4]([NH2:14])[C:5]=2[CH:11]=1

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 4874162,4-Diamino-6-(hydroxymethyl)pyrido[2,3-d]pyrimidine

Product 1

HCID 105628616-(Bromomethyl)-2,4-diaminopyrido [2,3-d]pyrimidine

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

The intermediate III-2 was prepared from 2,4-diaminopyrido [2,3-d]pyrimidine-6-methanol (III-1) by the procedure described in J. Med. Chem., 35:332 (1992). This particular preparation analyzed for a 1.75 HBr° 0.25 CH3COOH salt (formula wt. 406.7). The material was suitable for conversions to compound 33.

Workup

  1. customThis particular preparation

Sources & evidence

ORD record
ord-4519af7ad0c042d9b7c1e74387c6d76a
Source dataset
uspto-grants-1996_07
Patent number
US05536724

Reaction notes

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