Sodium hydride → 2-(2-oxopyrrolidin-1-yl)-N-(3-methyl-5,6,7,8-tetrahydrothieno[2,3-b]quinolin-4-yl)acetamide

HRID 1735139

反応式

HRID 1735139 の反応式
[H-].[Na+].[NH2:3][C:4]1[C:13]2[CH2:12][CH2:11][CH2:10][CH2:9][C:8]=2[N:7]=[C:6]2[S:14][CH:15]=[C:16]([CH3:17])[C:5]=12.[O:18]=[C:19]1[CH2:23][CH2:22][CH2:21][N:20]1[CH2:24][C:25](OC)=[O:26].[Cl-].[NH4+]>CN1CCCC1=O>[O:18]=[C:19]1[CH2:23][CH2:22][CH2:21][N:20]1[CH2:24][C:25]([NH:3][C:4]1[C:13]2[CH2:12][CH2:11][CH2:10][CH2:9][C:8]=2[N:7]=[C:6]2[S:14][CH:15]=[C:16]([CH3:17])[C:5]=12)=[O:26]

参加物

6

反応物 4

HCID 24758Sodium hydrideHCID 25517Ammonium ChlorideHCID 108835Methyl 2-oxo-1-pyrrolidineacetateHCID 152251184-Amino-3-methyl-5,6,7,8-tetrahydrothieno[2,3-b]quinoline

生成物 1

HCID 153850712-(2-oxopyrrolidin-1-yl)-N-(3-methyl-5,6,7,8-tetrahydrothieno[2,3-b]quinolin-4-yl)acetamide

試薬・触媒・溶媒 1

HCID 13387N-methyl-2-pyrrolidone溶媒

反応条件

温度
50 °C

実験手順

Into a suspension of 1.26 g of sodium hydride (60% content) in 15 ml of N-methylpyrrolidone, was added 3.28 g of 4-amino-3-methyl -5,6,7,8-tetrahydrothieno[2,3-b]quinoline at room temperature. The mixture was heated to 50° C. and stirred for 40 minutes. Thereafter, 4.72 g of methyl 2-oxo-1-pyrrolidine acetate was added dropwise to the mixture at 50° C. over a period of 30 minutes. After the stirring at 50° C. for 20 minutes, the mixture was cooled to 15° C. and poured into 130 ml aqueous solution containing 13.5 g of ammonium chloride.

後処理

  1. waitAfter the stirring at 50° C. for 20 minutes
  2. temperaturethe mixture was cooled to 15° C.

出典と根拠

ORDレコード
ord-c7bd126c74b34fce87ad06e4d24f7d7b
出典データセット
uspto-grants-1996_07
特許番号
US05536728

関連ノート

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