Potassium thiocyanate → 3-Methyl-4-thiocyanato-5-aminoisothiazole

HRID 1735689ノート

反応式

HRID 1735689 の反応式
[CH3:1][C:2]1[C:6](Br)=[C:5]([NH2:8])[S:4][N:3]=1.[C:9]([S-:11])#[N:10].[K+]>CO>[CH3:1][C:2]1[C:6]([S:11][C:9]#[N:10])=[C:5]([NH2:8])[S:4][N:3]=1

参加物

4

反応物 2

HCID 516872Potassium thiocyanateHCID 177499314-Bromo-3-methyl-1,2-thiazol-5-amine

生成物 1

HCID 146188853-Methyl-4-thiocyanato-5-aminoisothiazole

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

386 g of 3-methyl-4-bromo-5-aminoisothiazole and 200 g of KSCN in methanol are refluxed for 6 hours. The product crystallizes out on cooling. 800 ml of water are added and the product is filtered off under suction and washed with water.

後処理

  1. customThe product crystallizes out
  2. temperatureon cooling
  3. addition800 ml of water are added
  4. filtrationthe product is filtered off under suction
  5. washwashed with water

出典と根拠

ORDレコード
ord-7f6a56f2abef48c7b73daed48f3895b6
出典データセット
uspto-grants-1996_07
特許番号
US05538939

反応ノート

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