Sodium borohydride → 5,6-Difluoro-1-hydroxyindane

HRID 1735866ノート

反応式

HRID 1735866 の反応式
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][C:10]=1[F:11])[C:7](=[O:12])[CH2:6][CH2:5]2.[BH4-].[Na+]>C(O)C>[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][C:10]=1[F:11])[CH:7]([OH:12])[CH2:6][CH2:5]2

参加物

4

反応物 2

HCID 4311764Sodium borohydrideHCID 117689445,6-Difluoro-1-indanone

生成物 1

HCID 196993185,6-Difluoro-1-hydroxyindane収率 99.6%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

5,6-Difluoroindan-1-one (59.3 g, 0.353 mol) was dissolved in 1 L of ethanol and sodium borohydride (6.68 g, 0.176 mol) was added. The mixture was stirred for 48 hours and the ethanol was removed by evaporation under reduced pressure. The residue was partitioned between diethyl ether and water and the mixture was acidified with 1N hydrochloric acid. The mixture was dried over magnesium sulfate and filtered. The solvents were evaporated giving 5,6-difluoro-1-hydroxyindane (59.8 g) as an oil.

後処理

  1. customthe ethanol was removed by evaporation under reduced pressure
  2. customThe residue was partitioned between diethyl ether and water
  3. dry with materialThe mixture was dried over magnesium sulfate
  4. filtrationfiltered
  5. customThe solvents were evaporated

出典と根拠

ORDレコード
ord-d50c262ba03040d5b14ad2b0f408479b
出典データセット
uspto-grants-1996_07
特許番号
US05538988

反応ノート

読み込み中…