Trifluoroacetic acid → N-benzylaminosulfonamide
反応式
[S:1]([NH2:5])([NH2:4])(=[O:3])=[O:2].F[C:7](F)(F)C(O)=O.[C:13]1(OC)[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>ClCCl>[CH2:7]([NH:4][S:1]([NH2:5])(=[O:3])=[O:2])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1参加物
5
実験手順
The condensed sulfamide having a t-butoxycarbonyl protecting group obtained as Sample No. 1 of Example 1 is dissolved in a mixture of dichloromethane (15 vol.) and anisole (15 vol.) under ice cooling, and trifluoroacetic acid (15 vol.) is added thereto. The mixture is stirred for 50 minutes, and for 1 hour after the ice bath is removed. The reaction mixture is concentrated. The residue is recrystallized from a mixture of ether and petroleum ether (1:6) to give benzylsulfamide. Colorless crystals. Yield: 90%.
後処理
- customobtained as Sample No
- customfor 1 hour after the ice bath is removed
- concentrationThe reaction mixture is concentrated
- customThe residue is recrystallized from a mixture of ether and petroleum ether (1:6)
出典と根拠
- ORDレコード
- ord-40f5c0f92d9a4e858dab77033cb15f6b
- 出典データセット
- uspto-grants-1996_07
- 特許番号
- US05539102
反応ノート
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