Hydrochloric Acid → 2-(Thymin-1-ylcarbonylamino)-5-(t-butyloxycarbonyl-amino)pentanoic acid

HRID 1735949ノート

反応式

HRID 1735949 の反応式
C([O:3][C:4](=[O:29])[CH:5]([NH:17][C:18]([N:20]1[CH:28]=[C:26]([CH3:27])[C:24](=[O:25])[NH:23][C:21]1=[O:22])=[O:19])[CH2:6][CH2:7][CH2:8][NH:9][C:10]([O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:11])C.Cl>C(O)C.[OH-].[Na+]>[N:20]1([C:18]([NH:17][CH:5]([CH2:6][CH2:7][CH2:8][NH:9][C:10]([O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:11])[C:4]([OH:29])=[O:3])=[O:19])[CH:28]=[C:26]([CH3:27])[C:24](=[O:25])[NH:23][C:21]1=[O:22]

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 54034076HCID 54034076、化合物

生成物 1

HCID 190762582-(Thymin-1-ylcarbonylamino)-5-(t-butyloxycarbonyl-amino)pentanoic acid

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 14798Sodium Hydroxide溶媒

実験手順

The product from Example 11, 15, is dissolved in ethanol (500 mL) and to this added 2M sodium hydroxide (50 mL) and the reaction stirred for 12 hours. The reaction is neutralized with 2M HCl solution (50 mL) and evaporated to a small volume. This residue is diluted with water (250 mL) and extracted with dichloromethane (4×100 mL), dried, filtered, and evaporated to give a solid.

後処理

  1. customevaporated to a small volume
  2. additionThis residue is diluted with water (250 mL)
  3. extractionextracted with dichloromethane (4×100 mL)
  4. customdried
  5. filtrationfiltered
  6. customevaporated
  7. customto give a solid

出典と根拠

ORDレコード
ord-505deacc5ea842da833a8b854e216329
出典データセット
uspto-grants-1996_07
特許番号
US05539082

反応ノート

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