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llms.txt · MCPガイドプライバシーポリシー · 利用規約 · サポートv1.8.0

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反応

Hydrogen Peroxide → 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-((2-phenoxyacetyl)amino)-, 4-oxide, (2S,5R,6R)-

HRID 1736270

印刷プレビュー

反応式

HRID 1736270 の反応式

C(O)(=[O:15])CCCCCCCCCCCCC.OO.[CH3:19][C:20]1([CH3:42])[S:24][C@@H:23]2[C@H:25]([NH:28][C:29]([CH2:31][O:32][C:33]3[CH:34]=[CH:35][CH:36]=[CH:37][CH:38]=3)=[O:30])[C:26](=[O:27])[N:22]2[C@H:21]1[C:39]([OH:41])=[O:40].[K].P([O-])([O-])([O-])=O>C1(C)C=CC=CC=1.C(#N)C>[CH3:19][C:20]1([CH3:42])[S:24](=[O:15])[C@@H:23]2[C@H:25]([NH:28][C:29]([CH2:31][O:32][C:33]3[CH:34]=[CH:35][CH:36]=[CH:37][CH:38]=3)=[O:30])[C:26](=[O:27])[N:22]2[C@H:21]1[C:39]([OH:41])=[O:40]

参加物実験手順後処理出典と根拠反応ノート

参加物

7

反応物 4

HCID 784Hydrogen Peroxide

HCID 1061Phosphate

HCID 11005Myristic Acid

HCID 98651504-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-[(2-phenoxyacetyl)amino]-, potassium salt (1:1), (2S,5R,6R)-

生成物 1

HCID 1076024-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-((2-phenoxyacetyl)amino)-, 4-oxide, (2S,5R,6R)-

試薬・触媒・溶媒 2

HCID 1140Toluene溶媒

HCID 6342Acetonitrile溶媒

実験手順

To a mechanically stirred suspension of immobilized C. antarctica lipase (150 mg, according to example 1) in toluene (15 ml) and myristic acid (1 g, 4.6 mmol), was hydrogen peroxide (1.2 ml 60% (w/v), 21 mmol in all) added in four equal portions after 0, 2, 3 and 4 hours. Penicillin V-potassium salt (2.4 g, 6.2 mmol in all) was added in three equal portions after 2, 3 and 4 hours. The yields were determined by HPLC (Column: Supelco RP-18, 5 micro; Mobile phase: Acetonitrile 20% and pH 6.5 Phosphate buffer 80%; Flow: 1 ml/min. UV-detector). Full turnover was reached after 5 hours total reaction time.

後処理

additionTo a mechanically stirred suspension of immobilized C
additionadded in four equal portions after 0, 2, 3 and 4 hours

出典と根拠

ORDレコード: ord-e448e98d2ef349efae27b5d552dc70ee
出典データセット: uspto-grants-1996_07
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05541092

反応ノート

読み込み中…

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