N-(carbobenzyloxyaminosulfonyl)-2-piperidine-carboxylic acid methyl ester → N-(aminosulfonyl)-2-piperidinecarboxylic acid methyl ester
反応式
[CH3:1][O:2][C:3]([CH:5]1[CH2:10][CH2:9][CH2:8][CH2:7][N:6]1[S:11]([NH:14]C(OCC1C=CC=CC=1)=O)(=[O:13])=[O:12])=[O:4]>CO.[Pd]>[CH3:1][O:2][C:3]([CH:5]1[CH2:10][CH2:9][CH2:8][CH2:7][N:6]1[S:11]([NH2:14])(=[O:13])=[O:12])=[O:4]参加物
4
実験手順
A solution of N-(carbobenzyloxyaminosulfonyl)-2-piperidinecarboxylic acid methyl ester (29.8 g) in methanol (300 ml) under nitrogen was cooled to 0° C. and 1.8 g of 10% Pd/C was added. The mixture was placed into a Parr Apparatus and hydrogenated for 2 hours at 55 psi. The catalyst was removed on a pad of CELITE® and the filtrate was concentrated in vacuo and purified by flash silica gel chromatography (35-40% ethyl acetate/hexane) to afford 17 g (46%) of N-(aminosulfonyl)-2-piperidinecarboxylic acid methyl ester (Formula VII: R=CH3 ; R1 =H; R2 and R3 together=--(CH2)4 --) as a solid, m.p. 72°-74° C.