Thionyl Chloride → 6-Cyanonaphthalene-2-carbonyl chloride

HRID 1737070ノート

反応式

HRID 1737070 の反応式
[CH:1]1[C:10]2[C:5](=[CH:6][C:7]([C:11](O)=[O:12])=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[C:14]([NH2:16])=O.S(Cl)([Cl:19])=O>CN(C)C=O>[C:14]([C:2]1[CH:1]=[C:10]2[C:5](=[CH:4][CH:3]=1)[CH:6]=[C:7]([C:11]([Cl:19])=[O:12])[CH:8]=[CH:9]2)#[N:16]

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 211863766-(Aminocarbonyl)-2-naphthalenecarboxylic acid

生成物 1

HCID 124330916-Cyanonaphthalene-2-carbonyl chloride

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide触媒

実験手順

2.8 g of naphthalene-2,6-dicarboxylic acid monoamide, 10 ml of thionylchloride and 1 drop of dimethylformamide are refluxed for 5 hours. The clear yellow solution is evaporated down in vacuo and the solid evaporation residue is mixed with 20 ml of diethylether and 20 ml of petroleum ether, then stirred and suction filtered. The filter cake is washed with petroleum ether and diethylether and dried in vacuo.

後処理

  1. customThe clear yellow solution is evaporated down in vacuo
  2. customthe solid evaporation residue
  3. additionis mixed with 20 ml of diethylether and 20 ml of petroleum ether
  4. filtrationsuction filtered
  5. washThe filter cake is washed with petroleum ether and diethylether
  6. customdried in vacuo

出典と根拠

ORDレコード
ord-106617a06650425380cd019f87b3d912
出典データセット
uspto-grants-1996_07
特許番号
US05541343

反応ノート

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