4-Methylmorpholine → 3-Phenyloxycarbonyloxymethyl-3-methyloxetane

HRID 1737101ノート

反応式

HRID 1737101 の反応式
[O:1]([C:8](Cl)=[O:9])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH:11][CH2:12][C:13]1([CH3:17])[CH2:16][O:15][CH2:14]1.CN1CCOCC1>C(Cl)Cl>[C:2]1([O:1][C:8]([O:11][CH2:12][C:13]2([CH3:17])[CH2:16][O:15][CH2:14]2)=[O:9])[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

5

反応物 3

HCID 79724-MethylmorpholineHCID 15891Phenyl chloroformateHCID 1378373-Methyl-3-oxetanemethanol

生成物 1

HCID 189397703-Phenyloxycarbonyloxymethyl-3-methyloxetane

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒3 回

反応条件

温度
0 °C

実験手順

A 0.552 mL (4.42 mmol) sample of phenoxycarbonylchloride in 2 mL of methylene chloride was added to a solution of 376 mg (3.68 mmol) of 3-hydroxymethyl-3-methyloxetane and 60.7 mL (5.52 mmol) of 4-methylmorpholine in 2 mL of methylene chloride cooled in an ice bath. The mixture was stirred at 0° C. for 3.5 hours. The mixture was diluted with methylene chloride, which was washed with water, dried and concentrated. The crude product was chromatographed on silica gel, eluting with 20% ethyl acetate in hexane. The solvent was removed and the product dried to afford 0.582 g of the title compound, which was taken directly to the next step.

後処理

  1. temperaturecooled in an ice bath
  2. washwas washed with water
  3. customdried
  4. concentrationconcentrated
  5. customThe crude product was chromatographed on silica gel
  6. washeluting with 20% ethyl acetate in hexane
  7. customThe solvent was removed
  8. customthe product dried

出典と根拠

ORDレコード
ord-bfbf8b063833489693d5d40b0320cf79
出典データセット
uspto-grants-1996_07
特許番号
US05541334

反応ノート

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