Hydrazine hydrate (1:1) → 2-bromo-4-(6,7-dimethoxyphthalazin-1(2H)-on-4-yl)pyridine
反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:9]([C:14](=O)[C:15]2[CH:20]=[CH:19][N:18]=[C:17]([Br:21])[CH:16]=2)=[CH:10][C:11]=1[O:12][CH3:13])[C:6](O)=[O:7].O.[NH2:24][NH2:25]>C(O)C>[Br:21][C:17]1[CH:16]=[C:15]([C:14]2[C:9]3[C:5](=[CH:4][C:3]([O:2][CH3:1])=[C:11]([O:12][CH3:13])[CH:10]=3)[C:6](=[O:7])[NH:25][N:24]=2)[CH:20]=[CH:19][N:18]=1参加物
4
実験手順
3,4-Dimethoxy-6-(2-bromoisonicotinoyl)benzoic acid (15.2 g) and hydrazine monohydrate (15 ml) are added to ethanol (30 ml), and the mixture is heated under reflux for one hour. The reaction mixture is cooled with ice, and the precipitates are collected by filtration to give 2-bromo-4-(6,7-dimethoxyphthalazin-1(2H)-on-4-yl)pyridine (14.1 g).