Hydrazine hydrate (1:1) → 2-Bromo-4-(6,7-dimethoxyphthalazin-1-yl)pyridine

HRID 1739429ノート

反応式

HRID 1739429 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:8]([C:13](=O)[C:14]2[CH:19]=[CH:18][N:17]=[C:16]([Br:20])[CH:15]=2)=[CH:9][C:10]=1[O:11][CH3:12])[CH:6]=O.O.[NH2:23][NH2:24]>CO>[Br:20][C:16]1[CH:15]=[C:14]([C:13]2[C:8]3[C:5](=[CH:4][C:3]([O:2][CH3:1])=[C:10]([O:11][CH3:12])[CH:9]=3)[CH:6]=[N:24][N:23]=2)[CH:19]=[CH:18][N:17]=1

参加物

4

反応物 2

HCID 24654Hydrazine hydrate (1:1)HCID 218408403,4-Dimethoxy-6-(2-bromoisonicotinoyl)benzaldehyde

生成物 1

HCID 218408262-Bromo-4-(6,7-dimethoxyphthalazin-1-yl)pyridine

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of 3,4-dimethoxy-6-(2-bromoisonicotinoyl)benzaldehyde (4.5 g) in methanol (70 ml) is added dropwise hydrazine monohydrate (0.8 ml). The reaction mixture is cooled with ice, and the precipitates are collected by filtration, and recrystallized from methanol to give 2-bromo-4-(6,7-dimethoxyphthalazin-1-yl)pyridine (4.01 g) as yellow crystals.

後処理

  1. temperatureThe reaction mixture is cooled with ice
  2. filtrationthe precipitates are collected by filtration
  3. customrecrystallized from methanol

出典と根拠

ORDレコード
ord-daa5282d355343339542882c9bf68cc2
出典データセット
uspto-grants-1999_10
特許番号
US05965730

反応ノート

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