2-Hydroxy-5-methylbenzyl alcohol → Benzaldehyde, 2-hydroxy-5-methyl-

HRID 1739486

反応式

HRID 1739486 の反応式
[OH:1][CH2:2][C:3]1[CH:8]=[C:7]([CH3:9])[CH:6]=[CH:5][C:4]=1[OH:10]>C(Cl)(Cl)Cl.[O-2].[O-2].[Mn+4]>[OH:10][C:4]1[CH:5]=[CH:6][C:7]([CH3:9])=[CH:8][C:3]=1[CH:2]=[O:1]

参加物

4

反応物 1

HCID 2574522-Hydroxy-5-methylbenzyl alcohol

生成物 1

HCID 69184Benzaldehyde, 2-hydroxy-5-methyl-収率 20.7%

試薬・触媒・溶媒 2

HCID 178418406HCID 178418406、化合物触媒HCID 6212Chloroform溶媒

実験手順

2-Hydroxymethyl-4-methylphenol (3.1 g, 22.4 mMol) was dissolved in CHCl3 (95 ml). The solution was treated with manganese dioxide (8.7 g, 100 mmol) and the reaction stirred at ambient temperature overnight under an argon atmosphere. The reaction was then filtered through Celite and the solvent evaporated. The residue was subjected to chromatography (eluant: ethyl ether/hexane) to give 2-hydroxy-5-methylbenzaldehyde as a pale green solid (0.63 g, 20.7%).

後処理

  1. filtrationThe reaction was then filtered through Celite
  2. customthe solvent evaporated

出典と根拠

ORDレコード
ord-d860a9483f7040eca836722a1bc22f20
出典データセット
uspto-grants-1999_10
特許番号
US05965741

関連ノート

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