Sulfuric Acid → Succinanilic acid

HRID 1739631

反応式

HRID 1739631 の反応式
[C:1](Cl)(=[O:7])[CH2:2][CH2:3][C:4]([OH:6])=[O:5].[NH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1.S(=O)(=O)(O)O>C(#N)C>[C:10]1([NH:9][C:1](=[O:7])[CH2:2][CH2:3][C:4]([OH:6])=[O:5])[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1

参加物

5

反応物 3

HCID 1118Sulfuric AcidHCID 6115AnilineHCID 138186494-Chloro-4-oxobutanoic acid

生成物 1

HCID 7598Succinanilic acid収率 63.6%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

100 mg of succinic acid monochloride are dissolved in 2 ml of anhydrous acetonitrile. 1.5 equivalents of aniline (102 mg) are added at room temperature and the reaction mixture is kept stirred for 30 minutes. 100 ml of 0.005M sulfuric acid are then added and the solution is extracted with ethyl ether (3×3 ml). The ether phases are combined and washed with water to neutrality and then dried over anhydrous MgSO4. The ether is then filtered and evaporated under reduced pressure to give 90 mg of N-phenylsuccinamic acid.

後処理

  1. extractionthe solution is extracted with ethyl ether (3×3 ml)
  2. washwashed with water to neutrality
  3. dry with materialdried over anhydrous MgSO4
  4. filtrationThe ether is then filtered
  5. customevaporated under reduced pressure

出典と根拠

ORDレコード
ord-3ad1ad6d4aa94b4482afbffd8cb89dd9
出典データセット
uspto-grants-1999_10
特許番号
US05968794

関連ノート

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