Nitric Acid → 4-Amino-3-nitropyridine

反応式

[NH2:1][C:2]1[CH:7]=[CH:6][N:5]=[CH:4][CH:3]=1.S(=O)(=O)(O)O.[N+:13]([O-])([OH:15])=[O:14].NC1C([N+]([O-])=O)=NC=CC=1.NC(C)C#N>>[NH2:1][C:2]1[CH:7]=[CH:6][N:5]=[CH:4][C:3]=1[N+:13]([O-:15])=[O:14]

参加物

反応物 5

HCID 944Nitric Acid

HCID 1118Sulfuric Acid

HCID 17274-Aminopyridine

HCID 832812-Nitropyridin-3-amine

HCID 411840Propanenitrile, 2-amino-

生成物 1

HCID 5488034-Amino-3-nitropyridine

実験手順

4-Amino-3-nitropyridine was synthesized by a literature reference [Harris M. G. and Stewart R. Can. J. Chem. 55, 3800 (1977)]; by nitration of 4-aminopyridine with conc. sulfuric acid and fuming nitric acid. This aminonitropyridine was then converted to the aminopropionitrile derivative IV by the method described in Example 1.