Imidazole → 1-[(4-Nitrophenyl)(phenyl)methyl]-1H-imidazole
反応式
[NH:1]1[CH:5]=[CH:4][N:3]=[CH:2]1.Cl[CH:7]([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)[C:8]1[CH:13]=[CH:12][C:11]([N+:14]([O-:16])=[O:15])=[CH:10][CH:9]=1>C(#N)C>[N+:14]([C:11]1[CH:10]=[CH:9][C:8]([CH:7]([C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=2)[N:1]2[CH:5]=[CH:4][N:3]=[CH:2]2)=[CH:13][CH:12]=1)([O-:16])=[O:15]参加物
4
実験手順
Imidazole (121.8 g) was added to a mixture of 1-(chlorophenylmethyl)-4-nitrobenzene (88.7 g) in ACN (1000 ml) and the reaction mixture was stirred and refluxed for 24 hours. The solvent was evaporated. The residue was dissolved in toluene, washed with a 10% K2CO3 solution, dried (MgSO4), filtered and evaporated. The residue was purified by column chromatography over silica gel (eluent: CH2Cl2 /CH3OH 98/2). The pure fractions were collected and the solvent was evaporated, yielding 53 g (53%) of 1-[(4-nitrophenyl)phenylmethyl]-1H-imidazole (interm. 1-a).