Hydrochloric Acid → 5-Methylthio-6-trifluoromethyl-1-(3-carboxy Phenyl Carbamoyl)indoline

HRID 1740807ノート

反応式

HRID 1740807 の反応式
[CH3:1][S:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][C:11]=1[C:12]([F:15])([F:14])[F:13])[N:8]([C:16](=[O:29])[NH:17][C:18]1[CH:23]=[CH:22][CH:21]=[C:20]([C:24]([O:26]CC)=[O:25])[CH:19]=1)[CH2:7][CH2:6]2.[OH-].[Na+].Cl>C(O)C>[CH3:1][S:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][C:11]=1[C:12]([F:13])([F:14])[F:15])[N:8]([C:16](=[O:29])[NH:17][C:18]1[CH:23]=[CH:22][CH:21]=[C:20]([C:24]([OH:26])=[O:25])[CH:19]=1)[CH2:7][CH2:6]2

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 180051605-Methylthio-6-trifluoromethyl-1-(3-ethoxycarbonylphenyl carbamoyl)-indoline

生成物 1

HCID 180051075-Methylthio-6-trifluoromethyl-1-(3-carboxy Phenyl Carbamoyl)indoline収率 83%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a suspension of 5-methylthio-6-trifluoromethyl-1-(3-ethoxy carbonyl phenyl carbamoyl)indoline (3g, 7.1 mmol) in ethanol (30 ml) was added aqueous sodium hydroxide solution (SM) (7.1 ml, 35.5 mmol) and heated gently for 2 hours. It was then allowed to cool and acidified with aqueous hydrochloric acid (5M) forming a white precipitate which was filtered and dried to yield the product as a white solid (2.324 g, 83%), mp>200° C.

後処理

  1. temperatureheated gently for 2 hours
  2. temperatureto cool
  3. customforming a white precipitate which
  4. filtrationwas filtered
  5. customdried

出典と根拠

ORDレコード
ord-66b2ba4cad1547d897e401fb937ab82b
出典データセット
uspto-grants-1999_10
特許番号
US05972937

反応ノート

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