Water → Ethyl 1-[(2S)-2-oxiranylmethyl]-4-piperidinecarboxylate

HRID 1740837ノート

反応式

HRID 1740837 の反応式
[CH2:1]([O:3][C:4]([CH:6]1[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]1)=[O:5])[CH3:2].[C:12](=[O:15])([O-])[O-].[K+].[K+].O.[C:19](#N)[CH3:20]>>[CH2:1]([O:3][C:4]([CH:6]1[CH2:11][CH2:10][N:9]([CH2:19][C@H:20]2[CH2:12][O:15]2)[CH2:8][CH2:7]1)=[O:5])[CH3:2]

参加物

5

反応物 4

HCID 962WaterHCID 6342AcetonitrileHCID 11430Potassium CarbonateHCID 70770Ethyl 4-piperidinecarboxylate

生成物 1

HCID 33785968Ethyl 1-[(2S)-2-oxiranylmethyl]-4-piperidinecarboxylate

実験手順

A mixture of 5.7 g (2R)-glycidyl-tosylate (Fluka GmbH), 4 ml piperidine-4-carboxylic acid ethyl ester and 3.5 g potassium carbonate in 100 ml acetonitrile is heated for 2 h under reflux. After cooling the reaction mixture is admixed with 50 ml water and extracted three times each with 50 ml methylene chloride and 50 ml diethyl ether. After drying the combined organic phases over sodium sulfate and removing the solvent on a rotary evaporator, the residue is purified by means of column chromatography on silica gel (ethyl acetate/saturated methanolic ammonia 95/5). In this way 2.5 g (2S)-l-oxiran-2-ylmethyl-piperidine-4-carboxylic acid ethyl ester is obtained.

後処理

  1. temperatureis heated for 2 h
  2. temperatureunder reflux
  3. temperatureAfter cooling the reaction mixture
  4. extractionextracted three times each with 50 ml methylene chloride and 50 ml diethyl ether
  5. dry with materialAfter drying the combined organic phases over sodium sulfate
  6. customremoving the solvent
  7. customon a rotary evaporator
  8. customthe residue is purified by means of column chromatography on silica gel (ethyl acetate/saturated methanolic ammonia 95/5)

出典と根拠

ORDレコード
ord-6e5155291acb4976969a3d2d75646c6e
出典データセット
uspto-grants-1999_10
特許番号
US05972947

反応ノート

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