Hydrochloric Acid → 1-Benzofuran-5-amine
反応式
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]2[O:11][CH:10]=[CH:9][C:8]=2[CH:12]=1)([O-])=O.Cl>C(O)C.[Fe]>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]2[O:11][CH:10]=[CH:9][C:8]=2[CH:12]=1参加物
5
実験手順
To a solution of all of the 5-nitrobenzofuran in 90% ethanol (50 ml) kept at reflux were added small portions of Fe powder (in total 2.5 g) and concentrated HCl (in total 0.1 ml) during 10 min. The mixture was refluxed for another hour. The inorganic precipitates were filtered off and the mixture was poured onto brine and ethyl acetate (250 ml). Work-up of the organic phase afforded 1 g of crystalline 5-aminobenzofuran derivative.
後処理
- temperatureat reflux
- temperatureThe mixture was refluxed for another hour
- customThe inorganic precipitates
- filtrationwere filtered off
- additionthe mixture was poured onto brine and ethyl acetate (250 ml)
出典と根拠
- ORDレコード
- ord-459bfbe6978a4bc09bcb38c8b3e93dad
- 出典データセット
- uspto-grants-1999_10
- 特許番号
- US05972964
反応ノート
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