Sodium Carbonate → 4-methyl-5-pentyl-2-Pyridinamine
反応式
[CH3:1][C:2]1[C:7]([CH2:8][CH2:9][CH2:10][CH2:11][CH3:12])=[CH:6][N:5]=[C:4]([NH:13]C(=O)C(C)(C)C)[CH:3]=1.C(=O)([O-])[O-].[Na+].[Na+]>Cl>[CH2:8]([C:7]1[C:2]([CH3:1])=[CH:3][C:4]([NH2:13])=[N:5][CH:6]=1)[CH2:9][CH2:10][CH2:11][CH3:12]参加物
4
反応条件
- 温度
- 100 °C
実験手順
A suspension of 4-methyl-2-(trimethylacetyl)amino-5-(1-pentyl)-pyridine (233 mg, 0.89 mmol) in 2N hydrochloric acid (3 mL) was heated at 100° C. for 18 h. The solution was cooled to room temperature, made basic with 20% aqueous sodium carbonate and extracted with chloroform. The organic layer was dried (Na2SO4), and evaporated. The product was purified by silica gel column chromatography using 2% methanol/methylene chloride to give the title compound.
後処理
- temperatureThe solution was cooled to room temperature
- extractionextracted with chloroform
- dry with materialThe organic layer was dried (Na2SO4)
- customevaporated
- customThe product was purified by silica gel column chromatography
出典と根拠
- ORDレコード
- ord-5a3337f9291043979b1013cb8aae1d59
- 出典データセット
- uspto-grants-1999_10
- 特許番号
- US05972975
反応ノート
読み込み中…