Hydrochloric Acid → 6-Amino-4-methylnicotinic acid
反応式
[NH2:1][C:2]1[CH:7]=[C:6]([CH3:8])C(C#N)=[CH:4][N:3]=1.[OH-:11].[Na+].Cl.[CH2:14]([OH:16])[CH3:15]>O>[NH2:1][C:2]1[CH:7]=[C:6]([CH3:8])[C:15]([C:14]([OH:11])=[O:16])=[CH:4][N:3]=1参加物
6
実験手順
A solution of 2-amino-5-cyano-4-methylpyridine (600 mg, 4.50 mmol) in ethanol (7.5 mL) was treated with 10N sodium hydroxide (7.5 mL) for 24 h at reflux temperature. The mixture was cooled and diluted with water (30 mL). The pH was adjusted to 7 with conc. hydrochloric acid and 1N hydrochloric acid. The resulting solid was filtered, dried by suction, washed with ether, and dried in vacuo; yield 134 mg (20%).
後処理
- temperatureat reflux temperature
- temperatureThe mixture was cooled
- filtrationThe resulting solid was filtered
- customdried by suction
- washwashed with ether
- customdried in vacuo
出典と根拠
- ORDレコード
- ord-ef5ac309499b4f3e8dbf6cd0ea6d7ef5
- 出典データセット
- uspto-grants-1999_10
- 特許番号
- US05972975
反応ノート
読み込み中…